Risk Assessment of the Insecticide Movento 100 SC with the Active Substance Spirotetramat

Movento 100 SC is a new insecticide containing the active substance spirotetramat. The intended use in stone fruit, pome vegetables and ornamentals outdoors, lettuce, tomatoes cucumbers greenhouses.
 VKM was requested by Norwegian Food Safety Authority to consider possible health risk for operators related properties of SC; particular relevance effects spirotetramat on thyroid hormones, brain, thymus body weight observed dogs, reproductive rats. also asked fate behaviour with ingredient environment, ecotoxicological risks its use. assessment finalized meeting May 24. 2013, VKM’s Scientific Panel Plant Protection Products.
 conclusions are as follows:
 Health:
 concludes that shows toxic dogs rats could be relevant humans. Thyroid glands target organs oral subchronic toxicity studies from 19 mg/kg bw/day (600 ppm). Decreases circulating hormone levels were detected all three carried out (28-, 90-days 1-year) should considered toxicologically relevant. opinion it cannot excluded brain dilatation treatment-related, humans.
 Furthermore, effect proposes NOAEL 5 (200 ppm) based 1- year study acute neurotoxicity rats.
 supports/proposes:
 
 ADI: 0.05 bw/day.
 AOEL: ARfD: 1 Risk calculations show minimal if personal protective equipment used.
 Environment:
 metabolites not expected accumulate soil. It or any will reach concentrations groundwater above threshold level 0.1 μg/L when formulation applied according use.
 proposed application scheme Norway represents adverse terrestrial mammals, birds, earthworms, soil microorganisms. However, in-field sensitive species predatory mites crop excluded.
 bees providing used crops during flowering actively foraging.
 For aquatic organisms surface water, minimal, provided m buffer zone open water used.